Drug tolerance
In general we know that tolerance is the capability to hold out something. In the pharmacology point of view the term tolerance is very close to the above said meaning. To get better understanding of this term however it needs to have brief knowledge in the subjected related to potency of a drug. A drug’s power can be expressed in the terms of dose of the drug required to produce an assured effect to the user.
For example, relief from headache could be achieved with 650 mg of pain killer based on the kind of pain killer used. Actually fewer drugs is enough to produce effect to relieve headache.
Tolerance develops when the drug turn out to be less potent as a consequence of previous exposure to the drug. As the repeated drug administration makes to take more drugs to have the same effect as initially produced so tolerance develops with craving.
Tolerance can be differentiated in to expression behavioral tolerance and context specific tolerance. The expression behavioral tolerance refers to the drug’s less potency in disturbing a particular behavior subsequent to habitual exposure to the drug. In other terms it has a restricted meaning that is it works only when behavioral aspects have been revealed experimentally to have put in to the progress of tolerance.
Context specific tolerance refers to the tolerance only to certain specific features. The occurrence of context-specific tolerance facilitates give details why a lot of overdoses of physically abused drugs happen as soon as the drug is in use in a original condition—the novel context does not draw out compensatory reaction that neutralize the effects of the drug. Drug testing like medical drug testing, clinical drug tests, saliva drug screening, cup drug tests, and drug result screen are conducted to predict the tolerance to the drug.
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Tags: Clinical drug tests, cup drug tests, drug result screen, Medical drug testing, Saliva drug screening