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Tricyclic antidepressants are one of the most prescribed drugs when it comes to treating disorders in human behavior. The name by itself can give an idea about their chemical structure. The mechanism of action of tricyclic drugs is by inhibition of reuptake of presynaptic biogenic amine receptors in the brain. When the reuptake is prevented CNS stimulation is prolonged. The tricyclic antidepressants are available in many forms. The type of tricyclic being consumed determines which receptor will be blocked. antidepressant drug testing with TCA test card can help in tricyclic drug testing.

• Norepinephrine reuptake will be blocked by imipramine and its derivatives that have a tertiary amine side chain block.
• Norepinephrine reuptake will be selectively blocked by imipramine and its derivatives that have secondary amines. They have very less autonomic and anti-cholinergic effects.
• The tertiary amines of imipramine that are metabolized will have effect on norepinephrine after a certain level.
• Similarly there will be a different set of reuptake influence on serotonin when the donor has been taking clomipramine.
• Doxepin has greater anti-histaminergic action.

Abuse of such psychological drugs that are tricyclics can be detected for by anti depressant drug tricyclic urine testing. Tricyclic test card can be used to check the disposition of TCA in cases if it has been overdosed. High doses of TCA can cause gastrointestinal tract anti-cholinergic effects where the absorption of the GI tract can be slowed down making the GI system erratic. A spoilt GI system is the first step of overall health breakdown, essentially when the GI system is not functioning right in absorption, the brain does not function well, which in turn cause a low productivity of the person at the workplace or it might even slow down the activities of daily living of the person.

It is very important to be tested for tricyclic overdose in cases of people that are being treated with it. These drugs are metabolized and eliminated by hepatic metabolism. The metabolism of tricyclics varies between humans. Most of the metabolites of tricyclics to have elimination half-life which in most cases is twice that of the parent compound, due to this factor metabolites of tricyclics can be detection in the system for some extra time even after the primary tricyclic has been metabolized.

Another dangerous concept to patients in tricyclics is the “switch process” where the patients might have a transition from depression to being hippomaniac and also confusion, delirium and behavioral aberrations. So testing for overdosing is mandatory to prevent such bizarre consequences.

For any kind of help regarding choosing the right kind of Tricyclic Test Card feel free to contact the help desk of www.drugteststrips.com at info@drugteststrips.com or at toll free: 1 (866) 937-8483, and the consultations are absolutely free.

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Tags: anti depressant drug testing, Anti depressant drug tricyclic urine, TCA test card, tricyclic drug testing, tricyclic test card

This entry was posted on Thursday, November 13th, 2008 at 1:57 am and is filed under Urine DrugTest Kits . You can follow any responses to this entry through the RSS 2.0 feed. You can leave a response, or trackback from your own site.